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991.
S. N. Baker E. Olivier R. N. Lemon 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,123(4):397-411
The motor cortex contains a distributed map of muscles, with a single muscle represented over a wide cortical area. We have
searched for inter-connections between distant sites projecting to common muscles by delivering pairs of 20-μA single-pulse
intracortical microstimuli (ICMS) to sites separated by 1.5–2 mm in the hand-area primary motor cortex of two macaque monkeys
performing a precision grip task. The facilitation of hand- and forearm-muscle rectified EMG was measured. When stimuli were
delivered simultaneously, responses were quantified using a technique to correct for non-linearities inherent in the use of
averaged, rectified EMG. A spatial facilitation was seen for such simultaneous stimuli; however, it was of the same magnitude
as that occurring when ICMS was paired with stimulation of corticospinal axons in the pyramidal tract (PT), so that it was
likely to be spinal in origin. When two such distant sites were stimulated separated by a 10- or 20-ms delay, the second response
scaled with the level of background EMG in the same way as a response to the PT stimulus. By contrast, when the same site
was stimulated twice with these delays, the second response showed a facilitation compared with a similarly timed PT response.
There would therefore appear to be a local facilitation of the cortical output at these intervals, which is not seen between
distant sites. Antidromically identified pyramidal-tract neurones (PTNs) were recorded whilst stimuli were delivered to a
cortical site, with a distance between stimulating and recording electrodes of also 1.5–2 mm. The most common response was
a facilitation followed by a suppression. Six of eleven PTNs showed a facilitation in their discharge following this stimulation
(maximum connection strength s=0.19), 8/11 showed a suppression (maximum s=0.16). It is concluded that powerful inter-connections
do exist between distributed parts of the motor output and that there is widespread cortical activation after even a single
ICMS pulse. However, these inter-connections do not lead to interactions between cortical outputs following stimulation, as
assessed from the EMG. It is proposed that this is likely to reflect differences in the summation of output cells to local
versus remote stimulation.
Received: 10 March 1998 / Accepted: 2 June 1998 相似文献
992.
Castiello U Bonfiglioli C Peppard RF 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2000,135(2):251-258
The aim of the present study was to assess the effects of dopaminergic medication on the selection-for-action mechanisms in Parkinson's disease (PD). PD subjects were tested after not having taken medication for at least 12 h ("Off' state) and then retested 1-2 h after medication ("On" state). A three-dimensional kinematic system (ELITE, BTS, Italy) was used to record reach-to-grasp movements to a target object placed at a reaching distance of 30 cm. The target was presented alone or in the presence of distractor objects, which could be of either the same size (compatible distractor) or a different size (incompatible distractor). PD subjects in the Off state were significantly more affected by the presence of the incompatible distractor than in the On state. These results indicate that dopaminergic medication is of benefit in reducing interference effects when distractor objects evoke motor programs that differ from the motor program elicited by the target. Results are discussed in light of the role played by the striatal and mesocortical dopaminergic systems for response selection in basal ganglia disorders. 相似文献
993.
Studies were carried out on long-term changes in the synchronization of neuronal activity in networks including callosal cells
of the opposite hemispheres evoked by higher-frequency microstimulation in the motor cortex of anesthetized rats. The level
of synchronization was assessed in terms of the amplitude and width of peaks located symmetrically on, cross-correlograms
relative to the coordinate origin. Tetanization predominantly decreased synchronization in a group of initially background-active
neurons, while there was a significant number of synchronously firing neurons in a group of cells which became activated.
“Supernarrow” peaks appeared in interhemisphere interactions. There was a correlation between the type of modification of
“narrow” (<20 msec) and “intermediate” (30–80 msec) peaks and changes in the efficiencies of mono- and polysynaptic connections.
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 7, pp. 614–623, July, 1998. 相似文献
994.
目的:分析臂丛损伤后脊髓前角运动神经元表达GAP-43 mRNA及其蛋白的变化规律,探讨神经损伤再生的机制。方法:建立3种臂丛损伤模型:右C7前根撕脱(A组);右C7前根撕脱+同侧C5-T1后根断离(B组);右C7前根撕脱+右C5C6间脊髓半横断(C组)。用荧光定量RT-PCR方法检测术后14 d时 C7前角GAP-43 mRNA的表达量。用免疫组化方法检测术后1、 3、 7、14 d脊髓前角GAP-43免疫阳性运动神经元的表达。结果:对照组C7前角GAP-43 mRNA呈低表达,损伤组GAP-43 mRNA表达显著上调。损伤组术后1 d、3 d时均未见C7前角 GAP-43免疫阳性神经元,术后7 d各损伤组GAP-43免疫阳性神经元开始出现,14 d时免疫阳性神经元数目达到高峰。3组间比较,C组表达量最高,B组最低,A组居中。结论:臂丛损伤诱导运动神经元GAP-43 mRNA及其蛋白表达上调,GAP-43合成增加是神经元蛋白重组所致,与轴索再生和神经功能重建有关。 相似文献
995.
基于连续小波变换和支持向量机的手动想象脑电分类 总被引:10,自引:0,他引:10
对左右手运动想象脑电信号进行准确分类是脑-机接口(BCI)研究领域的重要问题。本文利用连续小波变换(CWT)提取脑电信号中相应的手动想象特征信号,并通过支持向量机(SVM)对特征信号进行分类,取得了较好的分类效果,然后经过分析SVM的学习算法,讨论了对于SVM的分类有着关键影响的时间成分,反映出传统的ERD/ERS计算方法可能出现的问题。 相似文献
996.
U. Sławin´ska F. Tyc˘ S. Kasicki R. Navarrete G. Vrbová 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,120(2):193-201
After partial denervation, the remaining motor units (MUs) of adult fast extensor digitorum longus muscle (EDL) expand their
peripheral field. The time course of this event was studied using tension measurement and recordings of electromyographic
(EMG) activity. The results show that after section of the L4 spinal nerve, when only 5.3 ± 0.63 of the 40 MUs normally supplying
EDL muscle remain, the force of individual motor units starts to increase between the 1st and 2nd week after the operation
and continues to do so for a further week. The drastic reduction of the number of motoneurones supplying the fast EDL leads
to an increase in activity of the remaining MUs. In the 1st week after partial denervation, there was a sharp increase in
the EMG activity of remaining motor units. During the next 12 days, this increase became less marked, but EMG activity remained
nevertheless significantly higher than that of the unoperated EDL muscle. Many MUs became tonically active during posture.
The EMG activity pattern during locomotion was also altered, so that the burst duration was positively correlated with the
step cycle duration. Moreover, shortly after partial denervation, the interlimb coordination was disturbed but returned to
its original symmetrical use 1–2 weeks later.
Received: 17 September 1996 / Accepted: 3 November 1997 相似文献
997.
Task-dependent exogenous cuing effects on reaction time in detection and discrimination tasks have been ascribed to delayed withdrawal of attention in discrimination tasks. Alternatively, these differences may be due to cue-induced response inhibition in detection tasks. Unimodal and crossmodal versions of the Posner paradigm were examined with short cue-target intervals. Targets above or below fixation required either detection or discrimination responses. Cuing effects were determined for the target-elicited P1 component and for the lateralized readiness potential (LRP). Task-dependent cuing effects on reaction time were found in the unimodal but not in the crossmodal version, but not for the P1 component. The LRP data indicated that inhibition of return in the unimodal detection task had a premotoric locus. These findings suggest that inhibition in the unimodal detection task resulted from speeded motor inhibition triggered by the visual cue. 相似文献
998.
J. Richard Jennings Maurits W. VAN DER Molen Riek J.M. Somsen Cynthia Terezis 《Psychophysiology》1990,27(4):385-395
The influence of inducing motor responses of low and high force at different times in the cardiac cycle was examined. A handgrip response was used which allowed the separation of response initiation from response completion. Based on earlier work, we expected initiation, rather than completion, to initiate poststimulus cardiac acceleration. We also thought that preparation for a high force response might alter preparatory changes of interbeat interval differently from preparation for a low force response. Fifteen college-aged male subjects performed a warned reaction time task in which a visual stimulus signalled a handgrip requiring either a high or a low force to close. NoGo trials in which an inhibit signal was presented occurred on 12% of the trials. Stimuli occurred either on the R-wave of the electrocardiogram or 300 ms later. Reaction speed was varied in different trial blocks by rewarding response times of 200 ms (+/- 50 ms), 300 ms, or 400 ms. Results based on the timing of response initiation were essentially identical to those based on the timing of response completion. High force relative to low force was associated with both earlier response initiation and earlier cardiac acceleration. Force did not alter preparatory cardiac deceleration. Force and response speed did, however, alter the level of heart rate after response occurrence. Thus, response initiation (or an earlier response process) appears to induce a cardiac acceleration whose level is influenced by the speed and force of the motor response. 相似文献
999.
The influence of motor responding and typical psychophysiological tasks on heart rate was tested by manipulating motor requirements of reaction time (RT) and time estimation (TE) tasks. Thirty-four volunteers were assigned randomly to four groups. Two groups squeezed a hand dynamometer at the start of a trial and the other two groups squeezed at the finish of the trial. The force of the squeeze was also manipulated: either 3 kg (3) or 7 kg (7). The four groups were Start 3, Start 7, Finish 3, and Finish 7. All subjects participated in the TE and RT tasks. The dependent variables were measurements of forearm flexor muscle tension, heart rate and skin conductance. It was found that the manipulations of when and with what force a person squeezed the dynamometer resulted in reliable group differences in muscle tension. The magnitude of acceleratory components of the triphasic (acceleration-deceleration-acceleration) cardiac response was amplified by tension. The magnitude of the deceleratory component seemed to depend on both muscle tension and stimulus processing. Except for the magnitude of the response-bound deceleration, RT and TE produced very similar heart rate responses, and skin conductance did not differ among groups. The data were interpreted as providing evidence that motor response acts as an amplifier for the phasic HR produced by common psychological paradigms. 相似文献
1000.
The present study aimed to further investigate whether the intracortical neural circuits within the primary motor cortex (M1) are modulated during ipsilateral voluntary finger movements. Single- and paired-pulse (interstimulus intervals, ISIs; 3 ms and 12 ms) transcranial magnetic stimulations of the left M1 were applied to elicit motor evoked potential (MEP) in the right first dorsal interosseous (Rt-FDI) muscle during voluntary contractions (10% and 30% maximum voluntary contraction) of the left FDI (Lt-FDI) muscle. F-waves of Rt-FDI muscle were recorded under these left index-finger conditions for ensuring that the excitability changes occur at the supraspinal level. MEPs were also recorded during motor imagery of the left index-finger abduction instead of overt movement. The results showed that, in single-pulse transcranial magnetic stimulation (TMS) paradigm, MEPs in Rt-FDI muscle were markedly enhanced during voluntary contractions of Lt-FDI muscle compared with the complete resting state. In paired-pulse TMS paradigm, the short intracortical inhibition was significantly reduced in proportion to increments of the ipsilateral muscle contraction, whereas the intracortical facilitation had no change. F-wave of Rt-FDI muscle was unchanged under these conditions, while MEP in Rt-FDI muscle was also enhanced during motor imagery of the left index-finger abduction. Based on the present results, it is suggested that the intracortical inhibitory neural circuits may be modulated in the transition from rest to activity of the ipsilateral homonymous muscle. The excitability changes in M1 might be induced by overflows of voluntary drive given to the ipsilateral limb, probably via the transcallosal pathway. 相似文献